Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230

Authors
Pelyvas, IF Toth, ZG Vereb, G Balla, A Kovacs, E Gorzsas, A Sztaricskai, F Gergely, P
Citation
If. Pelyvas et al., Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230, J MED CHEM, 44(4), 2001, pp. 627-632
Citations number
30
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
00222623 → ACNP
Volume
44
Issue
4
Year of publication
2001
Pages
627 - 632
Database
ISI
SICI code
0022-2623(20010215)44:4<627:SONCCT>2.0.ZU;2-8
Abstract
The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kin ase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle a re reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4 K230 at or below a concentration of 1 mM.