Biodistribution and radiation dosimetry of the dopamine transporter ligand[F-18]FECNT

F-18-labeled 2 beta -carbomethoxy-3 beta-(4-chlorophenyl)-8-(-2-fluoroethyl )nortropane ([F-18]FECNT) is a recently developed dopamine transporter liga nd with potential applications in patients with Parkinson's disease and coc aine addiction. Methods: Estimates of the effective dose equivalent and dos es for specific organs were made using biodistribution data from 16 Sprague -Dawley rats and nine rhesus monkeys. PET images from two rhesus monkeys we re used to calculate the residence time for the basal ganglia. The computer program MIRDOSE3 was used to calculate the dosimetry according to the meth odology recommended by MIRD. Results: The basal ganglia were the targeted t issues receiving the highest dose, 0.11 mGy/MBq (0.39 rad/mCi). The effecti ve dose equivalent was 0.018 mSv/MBq (0.065 rem/mCi), and the effective dos e was 0.016 mSv/MBq (0.058 rem/mCi). Conclusion: Our data show that a 185-M Bq (5-mCi) injection of [18F]FECNT leads to an estimated effective dose of 3 mSv (0.3 rem) and an estimated dose to the target organ or tissue of 19.4 mGy (1.93 rad).