A. Kamal et al., Chemoenzymatic synthesis of pyrrolo[2,1-b]quinazolinones: Lipase-catalyzedresolution of vasicinone, J ORG CHEM, 66(3), 2001, pp. 997-1001
A facile synthesis of bronchodilatory pyrrolo [2,1-b] quinazoline alkaloids
by azidoreductive cyclization strategy employing TMSCl-NaI and bakers' yea
st is described. Both the chemical and enzymatic methods are mild and take
place at room temperature in good yields. Further, synthesis and resolution
of vasicinone has been carried out by employing different lipases. It has
been observed that lipase PS provides acetate of (S)-vasicinone in 98% ee.