Reversible spastic paraparesis induced by high-dose intravenous methadone

Authors
Manfredi, PL Gonzales, GR Payne, R
Citation
Pl. Manfredi et al., Reversible spastic paraparesis induced by high-dose intravenous methadone, J PAIN, 2(1), 2001, pp. 77-79
Citations number
12
Categorie Soggetti
Neurology
Journal title
JOURNAL OF PAIN
ISSN journal
15265900 → ACNP
Volume
2
Issue
1
Year of publication
2001
Pages
77 - 79
Database
ISI
SICI code
1526-5900(200102)2:1<77:RSPIBH>2.0.ZU;2-Y
Abstract
High doses of parenteral opioids can cause multifocal myoclonus and seizure s. Spasticity has been reported in patients receiving intraspinal opioids. In this article, we describe a patient who developed reversible spastic par aparesis with prominent extensor spasms in the legs while receiving an infu sion of intravenous methadone at 100 mg/hr. We discuss clinical presentatio n and possible pathophysiologic mechanisms of opioid side effects on the so matic motor system.