The extent to which stigmatized interaction partners engender perceivers' t
hreat reactions (i.e., stigma-threat hypothesis) was examined. Experiments
1 and 2 included the manipulation of stigma using facial birthmarks. Experi
ment 3 included manipulations of race and socioeconomic status. Threat resp
onses were measured physiologically, behaviorally, and subjectively. Percei
vers interacting with stigmatized partners exhibited cardiovascular reactiv
ity consistent with threat and poorer performance compared with participant
s interacting with nonstigmatized partners, who exhibited challenge reactiv
ity. In Experiment 3, intergroup contact moderated physiological reactivity
such that participants who reported more contact with Black persons exhibi
ted less physiological threat when interacting with them. These results sup
port the stigma-threat hypothesis and suggest the utility of a biopsychosoc
ial approach to the study of stigma and related constructs.