Development of reaction using imines as a radical acceptor and its stereocontrol

This review summarizes the recent progress in the field of radical reaction of imine derivatives, and focuses on the new carbon-carbon bond constructi ng-methods especially based on intermolecular carbon radical addition to im ine derivatives. Among the wide range of radical accepters containing a car bon-nitrogen double bond, it was revealed that the oxime ethers were excell ent radical accepters, and a lot of studies have been explored by using oxi me ethers. Reactivity of imine derivatives and possible reaction pathways h ave also been presented. The reaction was extended to one-pot and/or multi- component reactions. Moreover, a high degree of stereocontrol in reaction o f acyclic and cyclic imine derivatives was achieved by using triethylborane and diethylzinc.