Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure
M. Guazzi et al., Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure, J AM COL C, 37(2), 2001, pp. 398-406
Citations number
27
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objectives We sought to compare the protective efficacy of enalapril and lo
sartan on lung diffusion in chronic heart failure (CHF).
Background In CHF, hydrostatic overload causes disruption of the alveolar-c
apillary membrane and depression of carbon monoxide diffusion (DCO); enalap
ril improves DCO through mechanisms still undefined; and saline infusion in
the pulmonary circulation worsens DCO, putatively because of an upregulate
d sodium transport to the alveolar interstitium. We investigated whether en
alapril modulates sodium handling and whether losartan shares the same prop
erties.
Methods In 29 patients with CHF, DCO, its membrane diffusion subcomponent (
DM) and right atrial and pulmonary wedge pressures were monitored during sa
line infusion, in the control condition, during enalapril therapy (20 mg/da
y) for two weeks and after crossover to losartan (50 mg/day) for two weeks
(first 20 patients), or after the combination of enalapril with aspirin (32
5 mg/day) for one week (last 9 patients).
Results Saline, 150 ml, lowered DCO (-7.9%; p < 0.01) and DM (-9.9%; P < 0.
01) without hydrostatic variations. Responses to 750 ml of saline were qual
itatively similar. After treatment with enalapril, baseline DCO (p < 0.01)
and DM (p < 0.01) were augmented; after sodium loading, the percent reducti
ons of DCO (p < 0.01) and DM (p < 0.01) were comparable to those before it,
resulting in higher absolute values. This suggests that the seater the gas
conductance improvement with enalapril, the lower the impedance with salin
e. Losartan was ineffective on gas transfer at rest and under salt challeng
e. Aspirin counteracted the benefits of enalapril.
Conclusions In CHF, enalapril protects lung diffusion, possibly through a p
rostaglandin-mediated modulation of sodium overfiltration to the alveolar i
nterstitium; losartan does not share this ability. (C) 2001 by the American
College of Cardiology.