The effects of contemporary use of coronary stents on in-hospital mortality

OBJECTIVES This study was designed to determine the effect of coronary sten ts on in-hospital mortality. BACKGROUND Despite extensive use of stents for percutaneous coronary interv entions (PCIs), their effect on serious in-hospital events, especially mort ality, is not well defined. METHODS A cohort study was performed using 16,811 consecutive native-vessel PCI procedures performed on patients in the Society for Cardiac Angiograph y & Interventions Registry from July 1, 1996, through December 31, 1998. Pa tients undergoing balloon-only angioplasty were compared with those receivi ng a planned or unplanned stent. Procedures with other devices were exclude d. Multivariable analyses adjusted for detailed clinical characteristics an d for individual laboratory. RESULTS Stents were associated with a significant reduction in in-hospital mortality (0.3%) compared with balloon procedures (0.6%; multivariable odds ratio [OR] 0.55; 95% confidence interval [CI] 0.34, 0.89; p = 0.014). The risk of emergency coronary bypass also was reduced by stenting (0.3% vs. 0. 7%; multivariable OR 0.47; 95% CI: 0.29, 0.76; p = 0.002). Adjustment for t he use of glycoprotein IIb/IIIa inhibitors did not change the results, and the effects of stenting relative to balloon procedures were similar in thos e procedures with and without glycoprotein IIb/IIIa blockade (p = 0.94). CONCLUSIONS This study suggests that coronary stenting, compared with ballo on procedures, reduces in-hospital mortality, independent of the clinical s etting. (C) 2001 by the American College of Cardiology.