Assessment of antianginal and antiischemic efficacy of sulodexide as a component of combination pharmacotherapy of high functional class angina

Antianginal and antiischemic efficacy of sulodexide as a component of combi nation therapy was studied by Holter ECG monitoring in patients with stable III--IV functional class angina. In addition to standard antianginal thera py which remained unchanged throughout 4 weeks of the study 25 patients rec eived sulodexide and 20 patients received aspirin. Supplementation with sul odexide augmented effect of traditional drugs and was associated with chang es of activated partial thromboplastin time and platelet count and with low ering of initially elevated concentrations of total cholesterol, triglyceri des, creatinine and fibrinogen.