Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease

Authors
Lambert, JC Mann, D Goumidi, L Harris, J Amouyel, P Iwatsubo, T Lendon, C Chartier-Harlin, MC
Citation
Jc. Lambert et al., Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease, LANCET, 357(9256), 2001, pp. 608-609
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
357
Issue
9256
Year of publication
2001
Pages
608 - 609
Database
ISI
SICI code
0140-6736(20010224)357:9256<608:EOTAPP>2.0.ZU;2-H
Abstract
Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) af fect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regio ns 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amo unt of A beta deposition was independent of APOE genotype in our cohort. Th ese findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzh eimer's disease pathology.