The combination of HLA-DR1 and HLA-DR53 protects against MS

Authors
Luomala, M Elovaara, I Ukkonen, M Koivula, T Lehtimaki, T
Citation
M. Luomala et al., The combination of HLA-DR1 and HLA-DR53 protects against MS, NEUROLOGY, 56(3), 2001, pp. 383-385
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
3
Year of publication
2001
Pages
383 - 385
Database
ISI
SICI code
0028-3878(20010213)56:3<383:TCOHAH>2.0.ZU;2-D
Abstract
The DRB1/3/4/5 loci from 97 patients with MS and 100 normal control subject s were analyzed. DRB1*15 increased the risk of MS (OR = 4.2, p < 0.0001), w hereas DR1 decreased the risk (OR = 0.30, p(c) = 0.005). In analyses of the DR1 risk in relation to DR51, DR52, and DR53 alleles, DR1 in combination w ith DR53 was found to have the strongest protective effect against MS in al l subjects (OR = 0.05, p < 0.0001) and in DRB1*15-negative subjects (OR = 0 .09, p(c) = 0.026). DR53 may be an important allele or haplotype, acting to gether with DR1 to protect against MS.