Citation
H. Shinotoh et al., Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET, NEUROLOGY, 56(3), 2001, pp. 408-410
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878
→ ACNP
Volume
56
Issue
3
Year of publication
2001
Pages
408 - 410
Database
ISI
SICI code
0028-3878(20010213)56:3<408:EODOBA>2.0.ZU;2-K
Abstract
Acetylcholinesterase (AChE) activities in the brain of three patients with
AD were measured once before and once during donepezil treatment (5 mg/d in
two patients, 3 mg/d in one patient) using PET and N-[C-11]methylpiperidin
-4-yl acetate. Donepezil reduced k(3) values, an index of AChE activity, in
the cerebral cortex by 39 +/- 5%. All patients showed some degree of sympt
omatic improvement, and it was concluded that this improvement was likely c
aused by improved cholinergic activity by inhibition of AChE in the brain.