A beta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice

Authors
Tomidokoro, Y Ishiguro, K Harigaya, Y Matsubara, E Ikeda, M Park, JM Yasutake, K Kawarabayashi, T Okamoto, K Shoji, M
Citation
Y. Tomidokoro et al., A beta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice, NEUROSCI L, 299(3), 2001, pp. 169-172
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
299
Issue
3
Year of publication
2001
Pages
169 - 172
Database
ISI
SICI code
0304-3940(20010223)299:3<169:ABAITI>2.0.ZU;2-8
Abstract
To clarify how A beta deposits induce secondary tauopathy, the presence of phosphorylated tau, glycogen synthase kinase 3 alpha (GSK3 alpha), GSK3 bet a, cyclin-dependent kinase 5 (CDK5), mitogen-activated protein kinase (MAPK ) and fyn were examined in the Tg2576 brain showing substantial brain A bet a amyloidosis and behavioral abnormalities. Phosphorylated tau at Ser199, T hr231/Ser235, Ser396 and Ser413 accumulated in the dystrophic neurites of s enile plaques. The major kinase for tau phosphorylation was GSK3 beta. Smal ler contributions of GSK3 alpha, CDK5 and MAPK were suggested. Thus, brain A beta amyloidosis has a potential role in the induction of tauopathy leadi ng to the mental disturbances of Alzheimer's disease, (C) 2001 Elsevier Sci ence Ireland Ltd. All rights reserved.