Clara cell secretory protein (CC16) gene polymorphism and schizophrenia inhumans

An increasing amount of evidence suggests that the pathophysiology of schiz ophrenia is associated with activation of the inflammatory response system, as indicated by lower serum concentrations of Clara cell secretory protein (CC16), an endogenous anti-inflammatory protein in patients with schizophr enia. In the present study, we investigated the genetic association between a functional polymorphism (A38G) in human CC16 gene and schizophrenia (248 Japanese schizophrenic patients and 206 healthy controls). No significant positive association between the CC16 gene polymorphism and schizophrenia w as observed. In addition, even when schizophrenic patients were divided int o those with a positive family history for schizophrenia and with a negativ e family history for schizophrenia, no significant association with A38G po lymorphism of the CC16 gene was observed. Our results suggest that the CC16 gene polymorphism do not confer increased susceptibility for schizophrenia . (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.