Pregnancy rates in sequential in vitro fertilization cycles by oocyte donors

Objective: To evaluate the clinical outcome of in vitro fertilization (IVF) treatment cycles from individual oocyte donors who underwent multiple sequ ential donations. Methods: We reviewed clinical outcome data from sequential anonymous oocyte donation cycles using donors who underwent multiple IVF stimulations. Dono rs were grouped by the interval between cycles and the cycle number (rank). The primary outcome measure was delivery rate by individual donor per retr ieval from the combined derivative fresh and frozen embryo transfers. Results: Duration and amount of gonadotropin therapy and the fertilization rates did not correlate significantly with the interval between cycles or c ycle rank. Cumulative delivered pregnancy rates for cycles 1-6 were 51.5%, 54.6%, 50.5%, 51.5%, 51.1%, and 57.6%, respectively. Delivered pregnancy ra tes did not vary by interval between cycles. Conclusion: Young healthy presumed or proven fertile women can reliably don ate oocytes for at least six cycles with the expectation of consistently hi gh pregnancy rates. (Obstet Gynecol 2001;97:201-4. (C) 2001 by The American College of Obstetricians and Gynecologists.).