Allergic reactions due to ibuprofen in children

Ibuprofen is 2-(4-isobutyl-fenyl)-propionic acid, which belongs to the same group of nonsteroidal antiinflammatory drugs (NSAIDs) as naproxen and keto profen, We present two instances of adverse reaction to pediatric ibuprofen , an acute urticaria and a fixed drug eruption, with tolerance to acetylsal icylic acid (ASA) and acetaminophen, in what seems to be hypersensitivity t o the propionic acid group. Although these reactions are very rare and ibup rofen is still very safe, we think it is important to know about the possib le side effects in order to recognize and treat them when they occur.