Idiopathic carpotarsal osteolysis with nephropathy

Idiopathic carpotarsal osteolysis is characterized by gradual lysis and res orption of bones, occurring mainly on hands and feet. It may be sporadic or hereditary and either form can manifest renal involvement. Nephropathy is seen more frequently and is more severe in the sporadic form. We present he rein two new cases of unrelated boys with the sporadic form associated with nephropathy. One of the patients had focal segmental glomerulosclerosis. T he other patient revealed isolated proteinuria.