A pharmacokinetic study of Neoral in childhood steroid-dependent nephroticsyndrome

Seven children with steroid-dependent nephrotic syndrome who were on stable remission under Sandimmun therapy were switched to Neoral at the same dosa ge. During the 4-month follow-up period, two patients relapsed, due to poor compliance in one of them. Serum creatinine remained stable in all patient s. Pharmacokinetic profiles were performed at day 0 while on Sandimmun and 4 weeks after conversion to Neoral. Following conversion to Neoral, the pea k concentration occurred earlier (2+/-1.4 h vs 3.9+/-2.4 h), and the maximu m concentration (677+/-386 ng/ml vs 488+/-265 ng/ml) and the area under the curve (3082+/-1536 ng/ml/h vs 2201+/-889 ng/ml/h) were higher. We conclude that Neoral results in an increased bioavailability of cyclosporine (CsA) as compared to Sandimmun in patients with steroid-dependent nephrotic syndr ome in remission.