Design of semicarbazones and their bio-isosteric analogues as potential anticonvulsants

A series of semicarbazones and hydrazones were prepared and evaluated for a nticonvulsant activity. Some compounds provided significant protection agai nst maximal electroshock (MES) and subcutaneous strychnine induced seizures (ScSty). Compound 2a emerged as the most active compound at a dose of 30 m g/kg in ScSty test. The compounds 1a. 1g and 2a-e showed significant potent iation of sedative and hypnotic activity of pentobarbitone sodium. Thus com pound 2a could serve as a prototype for future developments.