Biological activities of the plant-derived bisindole voacamine with reference to malaria

The in vivo antiplasmodial activity of voacamine was assessed in a 4-day te st. It was shown to exhibit in vivo activity with 25.4% and 43.4% inhibitio n of parasitaemia with 2.5 and 10 mg/kg, respectively. In synchronized cult ures, it was found to act on trophozoite and schizont stages of Plasmodium falciparum, Using the FMC29 strain of Plasmodium falciparum as parasite and the isobologram curve as a method to assess interaction in drug combinatio n, it was shown to lack any chloroquine-enhancing activity and its in vitro antiplasmodial effect was not potentiated by the chemosensitizer malagasha nine, Copyright (C) 2001 John Wiley & Sons, Ltd.