The effect of French maritime pine bark extract (PBE) on the gene expressio
n profile of HaCaT human keratinocytes was studied using high density filte
r arrays. The expression profile of both control and PBE-treated cells was
determined, Interestingly, PBE was shown to downregulate both calgranulin A
and B genes which are known to be upregulated in psoriasis and various der
matoses, Thus, PBE could be considered in human dermatoses, Copyright (C) 2
001 John Wiley & Sons, Ltd.