New polyurethanes derived from amino acids - Synthesis and characterization of alpha,omega-diaminooligopeptides by ring-opening polymerization of glutamate N-carboxyanhydrides

Strictly aminotelechelic oligopeptides with gamma -methylglutamate or gamma -benezylglutamate units were synthesized by oligomerization of the corresp onding N-carboxyanhydride initiated by ethylenediamine. The degree of polym erization (DP) was controlled by the ratio of NCA to ethylenediamine concen trations for reaction times of less than 1 h and DP = 20. The aminotelechel ic nature, which greatly depends on the conditions used during oligomerizat ion, was confirmed by amino end-group quantification. Characterization was achieved by H-1 and C-13 NMR and IR spectroscopy. (C) 2001 Elsevier Science B.V. All rights reserved.