Effects of skin occlusion on percutaneous absorption: An overview

Authors
Zhai, HB Maibach, HI
Citation
Hb. Zhai et Hi. Maibach, Effects of skin occlusion on percutaneous absorption: An overview, SKIN PH APP, 14(1), 2001, pp. 1-10
Citations number
51
Categorie Soggetti
da verificare
Journal title
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
ISSN journal
14222868 → ACNP
Volume
14
Issue
1
Year of publication
2001
Pages
1 - 10
Database
ISI
SICI code
1422-2868(200101/02)14:1<1:EOSOOP>2.0.ZU;2-M
Abstract
Skin occlusion produces profound changes, including hydration status, barri er permeability, epidermal lipids, DNA synthesis, microbial flora, and nume rous molecular and cellular processes. It often, but not always, increases percutaneous absorption of applied chemicals. This overview focuses on the effect of skin occlusion on percutaneous absorption. Copyright (C) 2001 S. Karger AG, Basel.