T. Kobayashi et al., OTOTOXIC EFFECT OF ERYTHROMYCIN ON COCHLEAR POTENTIALS IN THE GUINEA-PIG, The Annals of otology, rhinology & laryngology, 106(7), 1997, pp. 599-603
The mechanism of hearing loss due to the administration of intravenous
erythromycin was investigated in the aIbino guinea pig, and it was fo
und for the first time that this drug causes cochlear dysfunction. The
endocochlear potential (EP) and the cochlear microphonics (CM) record
ed at the first cochlear turn transiently decreased when erythromycin
was administered intravenously at dosages of 100 and 150 mg/kg. The av
eraged maximum decrease in EP was 16 mV (n = 5) and 33 mV (n = 5) for
100 and 150 mg/kg, respectively. The maximum decrease in the CM was ab
out 25% when the EP reached its lowest value with the injection of 150
mg/kg. A complete recovery of the EP and CM ensued within 20 minutes
after each erythromycin dose. The perilymphatic perfusion of 3 mmol/L
of erythromycin decreased the EP and CM; however, in contrast to the i
ntravenous administration, the decrease of the CM was nearly complete
and both the EP and CM were irreversible. Hearing loss due to intraven
ously administered erythromycin could likely be attributable to the tr
ansient dysfunction of the stria vascularis, although concomitant dysf
unction of the central auditory pathway cannot be excluded.