Suzuki arylation of 1,1-dibromo-1-alkenes: Synthesis of tetra-substituted alkenes

Authors
Bauer, A Miller, MW Vice, SF McCombie, SW
Citation
A. Bauer et al., Suzuki arylation of 1,1-dibromo-1-alkenes: Synthesis of tetra-substituted alkenes, SYNLETT, (2), 2001, pp. 254-256
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
2
Year of publication
2001
Pages
254 - 256
Database
ISI
SICI code
0936-5214(200102):2<254:SAO1SO>2.0.ZU;2-X
Abstract
1,1-Dibromo-1-alkenes were coupled with a variety of aryl boronic acids usi ng Suzuki conditions (PdCl2(PPh3)(2)/Na2CO3/ THF-H2O or DME-H2O/65-90 degre esC). The 1,1-dibromo-1-alkenes were prepared from ketones, and thus, the o verall process furnished tetra-substituted alkenes in a very efficient mann er.