General and user-friendly method for Suzuki reactions with aryl chlorides

Authors
Furstner, A Leitner, A
Citation
A. Furstner et A. Leitner, General and user-friendly method for Suzuki reactions with aryl chlorides, SYNLETT, (2), 2001, pp. 290-292
Citations number
42
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
2
Year of publication
2001
Pages
290 - 292
Database
ISI
SICI code
0936-5214(200102):2<290:GAUMFS>2.0.ZU;2-6
Abstract
Through the use of Pd(OAc)(2) and the sterically hindered imidazolium salt 5 (IPr . HCl) as the pre-catalyst mixture, aryl chlorides undergo efficient cross coupling reactions with 9-R-9-BBN derivatives (R = alkyl, allyl. alk ynyl, cyclopropyl) in the presence of KOMe as the base. This procedure is e asily scaleable and applies to electron poor and electron rich substrates w ith similar ease.