Condensation between isocyanates and carboxylic acids in the presence of 4-dimethylaminopyridine (DMAP), a mild and efficient synthesis of amides

Authors
Schuemacher, AC Hoffmann, RW
Citation
Ac. Schuemacher et Rw. Hoffmann, Condensation between isocyanates and carboxylic acids in the presence of 4-dimethylaminopyridine (DMAP), a mild and efficient synthesis of amides, SYNTHESIS-S, (2), 2001, pp. 243-246
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
2
Year of publication
2001
Pages
243 - 246
Database
ISI
SICI code
0039-7881(200102):2<243:CBIACA>2.0.ZU;2-1
Abstract
A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates is described. By using DMAP as a catalyst milder reac tion conditions are realised which also allow the conversion of alpha -chir al isocyanates, as well as alpha -chiral carboxylic adds without racemisati on.