Stereoselective synthesis of 2,6-dideoxy; 3,6-dideoxy; 2,3,6-trideoxy-inositol 1,4,5-trisphosphate and 6-deoxy-inositol 1,3,4,5-tetrakisphosphate analogues from 6-deoxy-D-inositol precursors

Authors
Benicio, AAA Da Silva, AD De Almeida, MV Da Silva, MM Gero, SD
Citation
Aaa. Benicio et al., Stereoselective synthesis of 2,6-dideoxy; 3,6-dideoxy; 2,3,6-trideoxy-inositol 1,4,5-trisphosphate and 6-deoxy-inositol 1,3,4,5-tetrakisphosphate analogues from 6-deoxy-D-inositol precursors, TETRAHEDRON, 57(7), 2001, pp. 1161-1167
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
7
Year of publication
2001
Pages
1161 - 1167
Database
ISI
SICI code
0040-4020(20010211)57:7<1161:SSO232>2.0.ZU;2-X
Abstract
The novel 2,6-dideoxy-2,2-difluoro; 2,6-dideoxy-2-fluoro; and 2,3,6-trideox y-2,3-difluoro-Ins(1,4,5)tris (dibutyl)phosphates and 6-deoxy-D-chiro-inosi tol 1,3,4,5-tetrakis(dibutyl)phosphate analogues were synthesized in optica lly pure form. Modification of Ins(1,4,5)P-3 and Ins(1,3,4,5)P-4 analogues by lipophilic substituents has been investigated in order to produce neutra l phosphate derivatives aimed to be incorporated in cell membrane for in vi vo evaluation. (C) 2001 Elsevier Science Ltd. All rights reserved.