Synthesis of a 3-aminopiperidin-2,5-dione as a conformationally constrained surrogate of the Ala-Gly dipeptide

Authors
Estiarte, MA Diez, A Rubiralta, M Jackson, RFW
Citation
Ma. Estiarte et al., Synthesis of a 3-aminopiperidin-2,5-dione as a conformationally constrained surrogate of the Ala-Gly dipeptide, TETRAHEDRON, 57(1), 2001, pp. 157-161
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
1
Year of publication
2001
Pages
157 - 161
Database
ISI
SICI code
0040-4020(20010101)57:1<157:SOA3AA>2.0.ZU;2-C
Abstract
The preparation of the Boc-{Ala-Gly}-OBn pseudopeptide 4 is reported. The k ey intermediate, aminoester 5b, was obtained by a cross-coupling reaction o f alaninezinc iodide 6 and the thioester of glycine 9. (C) 2000 Elsevier Sc ience Ltd. All rights reserved.