Enantioselective synthesis of alpha,beta-substituted beta-amino acids

Authors
Agami, C Cheramy, S Dechoux, L Melaimi, E
Citation
C. Agami et al., Enantioselective synthesis of alpha,beta-substituted beta-amino acids, TETRAHEDRON, 57(1), 2001, pp. 195-200
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
1
Year of publication
2001
Pages
195 - 200
Database
ISI
SICI code
0040-4020(20010101)57:1<195:ESOABA>2.0.ZU;2-5
Abstract
Chiral derivative 3 was shown to be a precursor of alpha and beta -substitu ted beta -amino acids as well as alpha,beta -disubstituted beta -amino acid s. The key steps of the procedure are a diastereoselective alkylation of sy nthon 3 by organocuprates reagents and a diastereoselective alkylation of t he: alkylated adduct. (C) 2000 Elsevier Science Ltd. All rights reserved.