Diterpenoid pyrones, novel blockers of the voltage-gated potassium channelKv1,3 from fungal fermentations

Authors
Goetz, MA Zink, DL Dezeny, G Dombrowski, A Polishook, JD Felix, JP Slaughter, RS Singh, SB
Citation
Ma. Goetz et al., Diterpenoid pyrones, novel blockers of the voltage-gated potassium channelKv1,3 from fungal fermentations, TETRAHEDR L, 42(7), 2001, pp. 1255-1257
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
7
Year of publication
2001
Pages
1255 - 1257
Database
ISI
SICI code
0040-4039(20010212)42:7<1255:DPNBOT>2.0.ZU;2-P
Abstract
The isolation, structure elucidation and chemical modification of nalanthal ide, a novel diterpenoid pyrone blocker of the voltage-gated potassium chan nel Kv1.3 are reported. The structure-activity relationship of the derivati ves with respect to various associated biological activities is also discus sed. (C) 2001 Elsevier Science Ltd. All rights reserved.