Improved procedure for the room temperature asymmetric phase-transfer mediated epoxidation of alpha,beta-unsaturated ketones

Authors
Lygo, B To, DCM
Citation
B. Lygo et Dcm. To, Improved procedure for the room temperature asymmetric phase-transfer mediated epoxidation of alpha,beta-unsaturated ketones, TETRAHEDR L, 42(7), 2001, pp. 1343-1346
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
7
Year of publication
2001
Pages
1343 - 1346
Database
ISI
SICI code
0040-4039(20010212)42:7<1343:IPFTRT>2.0.ZU;2-C
Abstract
Studies into the factors affecting the rate of reaction in the enantioselec tive epoxidation of alpha,beta -unsaturated ketones utilising Cinchona alka loid-derived quaternary ammonium phase-transfer catalysts are reported. Thi s has led to the identification of improved conditions for the room tempera ture epoxidation process, which require only I mol% catalyst and lead to is olation of the epoxide products in high enantiomeric excess. (C) 2001 Elsev ier Science Ltd. All rights reserved.