Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Authors
Cheung, M Harris, PA Lackey, KE
Citation
M. Cheung et al., Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one, TETRAHEDR L, 42(6), 2001, pp. 999-1001
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
6
Year of publication
2001
Pages
999 - 1001
Database
ISI
SICI code
0040-4039(20010205)42:6<999:SO2>2.0.ZU;2-I
Abstract
1,3-Dihydro-2N-indol-3-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2 -ones (azaoxindoles) are useful scaffolds that have been explored for vario us pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihy dro-6H-pyrrolo[2,3-d]pyrimidin-6-one (5) and its derivatives, and the appli cation of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles) as novel scaffold to kinase research areas. (C) 2001 Elsevier Science Ltd. Al l rights reserved.