A practical 'one-pot' synthesis of ethyl isoquinoline-3-carboxylate by domino reactions: a potential entry to constrained nonproteogenic amino acid derivatives

Authors
Meziane, MAA Royer, S Bazureau, JP
Citation
Maa. Meziane et al., A practical 'one-pot' synthesis of ethyl isoquinoline-3-carboxylate by domino reactions: a potential entry to constrained nonproteogenic amino acid derivatives, TETRAHEDR L, 42(6), 2001, pp. 1017-1020
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
6
Year of publication
2001
Pages
1017 - 1020
Database
ISI
SICI code
0040-4039(20010205)42:6<1017:AP'SOE>2.0.ZU;2-N
Abstract
Two simple and efficient 'one-pot' preparations of isoquinoline-3-carboxyla tes by domino reactions using phthalaldehydes and imidate (route A) or diet hyl aminomalonate (route B) are described. The third route involves the use of ethyl glycinate, aminoacetonitrile and phthalaldehyde which yields the respective ethyl isoquinoline-3-carboxylate and isoquinoline-3-carbonitrile . (C) 2001 Elsevier Science Ltd. All rights reserved.