Solution-phase combinatorial synthesis of isoxazolines and isoxazoles using [2+3] cycloaddition reaction of nitrile oxides

Authors
Kang, KH Pae, AN Il Choi, K Cho, YS Chung, BY Lee, JE Jung, SH Koh, HY Lee, HY
Citation
Kh. Kang et al., Solution-phase combinatorial synthesis of isoxazolines and isoxazoles using [2+3] cycloaddition reaction of nitrile oxides, TETRAHEDR L, 42(6), 2001, pp. 1057-1060
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
6
Year of publication
2001
Pages
1057 - 1060
Database
ISI
SICI code
0040-4039(20010205)42:6<1057:SCSOIA>2.0.ZU;2-Y
Abstract
An efficient way to construct a library of isoxazoles and isoxazolines was developed by solution-phase 1,3-dipolar cycloaddition reaction of nitrile o xides with olefins and alkynes followed by precipitation of the products as HCl salts. (C) 2001 Elsevier Science Ltd. All rights reserved.