HLA-B*07 allele frequencies and haplotypic associations in Koreans

Ne have investigated the frequencies of HLA-B*07 alleles and their haplotyp ic associations with HLA-A, -C and -DRB1 loci in 489 healthy unrelated Kore ans, including 214 parents from 107 families. All of the 45 samples (9.2%) typed as B7 by serology were analyzed for B*07 alleles using polymerase cha in reaction (PCR)-single strand conformation polymorphism (SSCP) method Two different B*07 alleles were detected: B*0702 (allele frequency 0.041) and B*0705 (0.005). Two characteristic haplotypes showing strong linkage disequ ilibrium in Koreans were A*2492-Cw*07-B*0702-DRB1*0101 (haplotype frequency 0.028) and A*2901-B*0705 DRB1*0803 (0.005). The characteristic haplotype A *2901-B*0705-DRB1*0803, found in 100% (5/5) of B*0705-positive individuals, has not been previously described in other ethnic groups. HLA-B7 alleles c omprise distinctive extended haplotypes in the Korean population The probab ility of HLA-B7 allele mismatches among ABDR-matched unrelated donor-recipi ent pairs is expected to be low in Koreans.