Evaluation of salivary sialic acid level and Cu-Zn superoxide dismutase activity in type 1 diabetes mellitus

In this study, our aim was to determine whether or not type 1 diabetes mell itus affects salivary sialic acid level and SOD activity. For this purpose, unstimulated saliva specimen was collected. Saliva sialic acid level and S OD activity were measured by the methods of Warren and Sun, respectively. W e found significantly decline in salivary sialic acid level and SOD activit y. The decrease of salivary sialic acid level in type 1 diabetes may be due to changes in the activities of the enzymes taking part of in the synthesi s and catabolism of sialic acid. The main reason for the decrease of saliva ry SOD activity may be increased glycation of the enzyme and/or deleterious effect of increased free oxygen radicals by glycated proteins on SOD activ ity in diabetes. We conclude the decline both in sialic acid and SOD in sal iva may be a possible factor leading to oral complications of diabetes mell itus.