Post-translational acetylation of core histones is an enigmatic process. Th
e identification of histone acetyltransferases and deacetylases as co-regul
ators of transcription in yeast and vertebrates has advanced our understand
ing of the biological role of histone acetylation and also improved our gen
eral insight into the molecular network of gene regulation. Basic features
of histone acetylation in plants resemble those of other eukaryotes but the
re are differences, which are reflected in novel classes of histone deacety
lase. Investigating histone acetylation in higher plants might reveal regul
atory pathways distinct from animals, yet of essential importance for gene
expression in plants.