Physical trauma,,dietary factors, certain toxins, immune mediated disorders
, and vesicular stomatitis virus (VSV) infection are known causes of stomat
itis in horses. There is evidence that some outbreaks of equine stomatitis
are caused by as yet unidentified infectious agents. It remains to be deter
mined whether stomatitis is an emerging equine infectious disease, or if th
e increase in reported cases is simply the result of greater public awarene
ss as a consequence of widespread outbreaks of VSV in the southwestern Unit
ed States in recent years. Focused laboratory and epidemiological studies a
re necessary to more adequately define non-VS related infectious and noninf
ectious causes of equine stomatitis.