Analysis of HLA antigens in Croatian patients with psoriasis

Citation
M. Kastelan et al., Analysis of HLA antigens in Croatian patients with psoriasis, ACT DER-VEN, 2000, pp. 12-13
Citations number
13
Categorie Soggetti
Dermatology,"da verificare
Journal title
ACTA DERMATO-VENEREOLOGICA
ISSN journal
00015555 → ACNP
Year of publication
2000
Supplement
211
Pages
12 - 13
Database
ISI
SICI code
0001-5555(2000):<12:AOHAIC>2.0.ZU;2-F
Abstract
In common with most autoimmune diseases, psoriasis is associated with some HLA antigens, We studied the distribution of HLA antigens in Croatian patie nts with psoriasis: 108 patients were divided into groups according to fami ly history and age of disease onset. KLA antigens were analyzed serological ly and HLA-C alleles were analyzed using polymerase chain reaction. We foun d significant increases in HLA-AZ, -B17, -B37 and -B13 antigens and highly significant increases in HLA-Cw*0602 and DR7 antigens in psoriatic patients compared with controls. Patients with type I psoriasis (early onset, posit ive family history) showed highly significant associations with Cw*0602 [p< 0.00001; relative risk (RR)=14.45] and DR7 (p<0.00001; RR=15.09) antigens. Patients with type II psoriasis (late onset, no family history) had a signi ficant association with Cw*03 antigen (p=0.008; RR=0.17). In conclusion, HL A-B13, -B17, Cw*0602 and -DR7 antigens are associated with a significant ri sk of psoriasis in the Croatian population and the Cw*0602 allele has the s trongest association, especially for type I psoriasis.