The usefulness of EEG, exogenous evoked potentials, and cognitive evoked potentials in the acute stage of post-anoxic and post-traumatic coma

Three-modality evoked potentials (TMEPs) have been used for several years i n association with the EEG as a diagnostic and prognostic tool in acute ano xic or traumatic coma. Cognitive EPs have been recently introduced. EEG and cognitive EPs provide functional assessment of the cerebral cortex. TMEP p arameters can be described by two indices: the index of global cortical fun ction (IGCF) and the index of brainstem conduction (IBSC). Although it remains a unique tool for epilepsy assessment, the value of EEG is largely limited by its high sensitivity to the electrical environmental noise, its dependence on sedative drugs. and its inability to test the bra instem. Major TMEP alterations (absence of cortical activities more than 24 hours after the onset of post-anoxic coma, major pontine involvement in he ad trauma) are associated in all cases with an ominous prognosis (death or vegetative state). However even if mild TMEP changes are associated with a good prognosis in 65% (post-anoxic coma) to 90% (head trauma) of cases, som e patients never recover despite exogenous TMEPs that are only mildly alter ed in the acute stage. Thus, cognitive EPs can usefully complement exogenou s EPs as a prognostic tool in coma. Indeed, even if the absence of cognitiv e EPs in comatose patients does not have any prognostic value, their presen ce implies a very high (more than 90%) probability of consciousness recover y. The major technical challenge for the future will be the development of reliable tools for continuous EEG and TMEP monitoring.