Mucosal pathology of the foregut associated with food allergy and recurrent abdominal pains in children

To determine whether children with recurrent abdominal pain (RAP) include a n excess of children with food allergy (FA), this study examined a consecut ive series of 84 children (43M, 41F, mean age 7.9 y, range 1.6-15 y) referr ed during 1 y to 2 university hospitals. In addition to a clinical examinat ion, the patients underwent gastroduodenoscopy with three biopsy specimens, skin-prick and patch tests, and comprehensive laboratory tests for atopic allergy. Based on an open elimination-challenge test, a total of 28 (33%) s ubjects were diagnosed for FA. In the whole material, specific endoscopic a bnormalities were found in 38 (45%) subjects: oesophagitis in 17, gastric e rosions in 8, lymphonodular duodenitis in 12 and erosive duodenitis in 5. F A showed a close relationship with duodenal lesions, but no significant ass ociation with oesophagitis and gastritis. The histological findings were mi ld, although some alterations could be observed in up to 66 (79%) subjects, equally often in patients with and without FA. None showed villous atrophy or severe infiltration of eosinophilic or mononuclear cells. Slightly incr eased densities of eosinophilic cells were significantly associated with en doscopic findings, especially oesophagitis. At least one positive skin-pric k test with food allergens was found in 11 subjects and a positive patch te st in 21 subjects, but neither showed an association with the endoscopic or histological findings, or even with clinical FA. Conclusion: Since the children with FA showed significantly more often conc omitant mucosal pathology of the foregut than those without FA, FA may be c onsidered one of the major factors underlying RAP. The report suggests the trial of an elimination diet in cases with RAP if lymphonodular hyperplasia or duodenitis is seen on gastroduodenoscopy.