Synthesis of chiral crystallization processes

A process synthesis procedure is presented for the resolution of racemic mi xtures by crystallization. The phase behaviors of racemic mixtures and of t hose in the presence of solvents and resolving agents are discussed. The co rresponding separation schemes are synthesized by considering the separatio n steps in a flowsheet as movements on a phase diagram. Separations with an d without involving racemization and deracemization are considered. The pro cedure is illustrated with several examples, including the manufacture of i buprofen and naproxen.