Nonerosive reflux disease - Current concepts and dilemmas

Nonerosive reflux disease is defined as the presence of typical symptoms of gastroesophageal reflux disease caused by intraesophageal acid in the abse nce of visible esophageal mucosal injury at endoscopy. Recent studies demon strate that it is a chronic disease with a significant impact on quality of life, and it is very common in primary care settings. Treatment with acid inhibitory agents is effective, and proton pump inhibitors are the most eff ective form of therapy. (C) 2001 by Am. Coll. of Gastroenterology.