Short-term variation in air pollution and in lung function among never-smokers - The Swiss study on air pollution and lung diseases in adults (SAPALDIA)

The present analysis was directed at investigating associations between sho rt-term variations in air pollutant levels (NO2, total suspended particulat es [TSP], O-3) and cross-sectional lung function (FVC, FEV1, and forced exp iratory flow at 25% to 75% of FVC [FEF25-75]) within a random sample of 3,9 12 adult never-smokers from eight areas of Switzerland (i.e., participants in the Swiss Study on Air Pollution and Lung Diseases in Adults [SAPALDIA] cross-sectional study, 1991). Within each local data set, the logarithms of FVC, FEV1, and FEF25-75 were regressed against the 24-h-means of NO2 and T SP and the 8-h mean of O-3 (10:00 A.M. to 6:00 P.M.) on the examination day , with control for subjects' sex, age, height and weight, seasonal fluctuat ions and weekly cycles and meteorologic factors. On average, a 10-mug/m(3) increment in the daily level of NO2 TSP, and O-3 was associated with decrem ents in FEV, of 0.67% (95% confidence interval [CI]: 0.13% to 1.21%), 0.46% (95% CI: 0.14% to 0.78%), and 0.51% (95% CI: 0.13% to 0.88%), respectively . Moreover, 10-mug/m(3) increments in NO2 and TSP were associated with decr ements in FVC of 0.73% (95% CI: 0.22% to 1.23%) and 0.36% (95% CI: 0.06% to 0.66%), respectively, and a 10-mug/m(3) increment in O-3 was associated wi th a decrement in FEF25-75 of 1.04% (95% CI: 0.22% to 1.85%). Our results s uggest that FVC, FEV1, and FEF25-75 vary with the daily level of NO2, TSP, and O-3, but that these measures of lung function do not allow separation o f the effects of particulates from those of NO3.