Metastatic soft tissue squamous cell carcinoma

Metastatic squamous cell carcinoma of the soft tissue is extremely rare. We report two patients with soft tissue metastasis from squamous cell carcino ma of the cervix in one and scalp in another. Case 1: A 63-year-old black w oman with a history of cervical cancer presented with a painful mass over t he right scapula, An incisional biopsy revealed squamous cell carcinoma. Sh e underwent radiation treatment followed by wide local excision with en blo c resection and a myocutaneous flap closure. Case 2: A 46-year-old white ma n with a history of squamous cell carcinoma of the scalp and two kidney tra nsplantations requiring long-term immunosuppression presented with a 2-mont h history of a left proximal arm mass. Magnetic resonance imaging revealed that the mass was within the triceps muscle and fixed to the humerus, Biops y revealed squamous cell carcinoma. He underwent a shoulder disarticulation for tumor invasion into the adjacent humerus and neurovascular bundles. Th e patients remain disease-free at 12 and 8 months, respectively. To our kno wledge there are no reports of soft tissue squamous cell carcinoma metastat ic from the cervix and only rare cases from the lung, head, and neck. The o ptimal mode of treatment and prognosis is undefined in these patients becau se of its rare incidence. Surgery and radiation with curative intent were u se.