Circulating interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and soluble ICAM-1 in patients with chronic stable angina and myocardial infarction

The changes in serum concentrations of cytokines such as interleukin-1 (IL- 1) beta, interleukin-6 (IL-6), tumor necrosis factor (TNF) alpha and a solu ble-intercellular adhesion molecule (sICAM-1)has been investigated in patie nts with stable angina and acute myocardial infarction. Thirty-four patient s with stable angina (SA), 15 with acute myocardial infarction (AMI), and 2 0 subjects in the control (C) group were included in the study. The mean serum concentrations of sICAM-1, IL-1-beta, IL-6, and TNF-alpha di ffered significantly among the three groups. Serum concentrations of IL-1 b eta, sICAM-1, and TNF-alpha were comparable in the AMI and SA groups and hi gher than those found in the C group (p < 0.001). The serum concentration o f IL-6 was more than twice as high in the AMI group as compared to the othe r two groups (p < 0.001). The mean serum concentrations of IL-1 beta, TNF-a lpha, and IL-6 were comparable in the AMI and SA groups and higher than in the C group.