Herpes simplex virus type 1 (HSV-1)-induced retinitis following herpes simplex encephalitis: Indications for brain-to-eye transmission of HSV-1

Citation
J. Maertzdorf et al., Herpes simplex virus type 1 (HSV-1)-induced retinitis following herpes simplex encephalitis: Indications for brain-to-eye transmission of HSV-1, ANN NEUROL, 49(1), 2001, pp. 104-106
Citations number
9
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
49
Issue
1
Year of publication
2001
Pages
104 - 106
Database
ISI
SICI code
0364-5134(200101)49:1<104:HSVT1(>2.0.ZU;2-G
Abstract
Herpes simplex encephalitis is a severe neurological disease with high mort ality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In th e present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brai n-to-eye transmission of HSV-1 in these patients.