Background. Lung transplantation has been used effectively as a therapeutic
tool in end-stage pulmonary diseases, but organ shortages have restricted
its use. There is growing interest in alternative organ sources such as org
ans from circulation-arrested cadavers, so called non-heart-beating donors.
Methods. We examined the effects of postmortem rapid in situ cadaver lung c
ooling by bilateral chest cavity flushing (group 2) and by pulmonary artery
flush through right heart catheterization followed by pleural cavity flush
ing (group 3) on pulmonary function and morphology in a rabbit non-heart-be
ating donor model. The results were compared with those in a control group
of heart-beating donors (group 1).
Results. At the end of a 2-hour reperfusion period, there were no significa
nt differences in mean pulmonary artery pressure, pulmonary vascular resist
ance, pulmonary compliance, arteriovenous oxygen, pulmonary wet to dry weig
ht ratio, and lung morphology between the three groups.
Conclusions. Our study demonstrates that using bilateral chest cavity flush
ing with or without pulmonary flush protects the function and morphology of
cadaver lungs and renders them suitable for lung transplantation. (C) 2001
by The Society of Thoracic Surgeons.