RING TRANSFORMATION OF 5-AMINO (OR ACYLAMINO)-6-HYDROXY (OR BENZOYLOXY)METHYLPYRIMIDIN-4(3H)-ONES INTO 1H-IMIDAZOLES

Authors
UEDA T ASAI S OIJI K NAGAI S NAGATSU A SAKAKIBARA J
Citation
T. Ueda et al., RING TRANSFORMATION OF 5-AMINO (OR ACYLAMINO)-6-HYDROXY (OR BENZOYLOXY)METHYLPYRIMIDIN-4(3H)-ONES INTO 1H-IMIDAZOLES, Journal of heterocyclic chemistry, 34(3), 1997, pp. 761-764
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
3
Year of publication
1997
Pages
761 - 764
Database
ISI
SICI code
0022-152X(1997)34:3<761:RTO5(A>2.0.ZU;2-O
Abstract
Treatment of 5-acylamino-6-hydroxy (or benzoyloxy)methyl-3-phenylpyrim idin-4(3H)-one 5,10 with 5% aqueous sodium hydroxide in ethanol gave y l-5-hydroxymethyl-4-phenylcarbamoyl-1H-imidazoles 7,11. Oxidation of 5 -amino-6-benzoyloxymethyl-3-phenylpyrim-4(3H)-one 9 in the presence of copper(II) chloride in alcohol gave oxy-5-alkoxymethyl-4-phenylcarbam oyl-1H-imidazoles 12a,b accompanied by -amino-6-alkoxymethyl-3-phenylp yrimidin-4(3H)-ones 13a,b.